Hyperemesis gravidarum, a literature review.
نویسندگان
چکیده
Hyperemesis gravidarum (HG) is a condition causing severe nausea and vomiting in early pregnancy often resulting in hospital admission. The incidence of HG is approximately 0.5% of live births, said to be higher in multiple pregnancies, hydatidiform mole and other conditions associated with increased pregnancy hormone levels. Both the aetiology and pathogenesis of HG remain unknown. We conducted a literature review (1966-now) to summarize the current evidence on the aetiology and pathogenesis of HG. The potential role of pregnancy-related hormones such as progesterone, estrogen and HCG has been widely studied; however, various other hormones such as leptin, placental growth hormone, prolactin, thyroid and adrenal cortical hormones have been implicated in the aetiology of HG. In addition to endocrinological hypotheses, the rationale and evidence considering infectious, immunological, psychological, metabolic and anatomical causes for HG have been analysed here. Many studies suffer from the low number of patients included, the variable definition used for HG and varying assay methodology used in studies of hormone measurement. This review highlights the need for more extensive studies addressing the pathogenesis and aetiology of HG.
منابع مشابه
Wisconsin Medical Journal
Doctor Philip is with the University of Wisconsin, Department of Family Practice, Eau Claire, Wis. Address reprint requests to Binu Philip, DO, 807 S Farwell, Eau Claire, Wis 54701 ABSTRACT Nausea and vomiting commonly occur in pregnant women. Hyperemesis gravidarum is a severe form of nausea and vomiting rarely occurring in pregnancy. Between 0.3% and 2% of all pregnant women suffer from hyper...
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Hyperemesis gravidarum is a complex condition with a multifactorial etiology characterized by severe intractable nausea and vomiting. Despite a high prevalence, studies exploring underlying etiology and treatments are limited. We performed a literature review, focusing on articles published over the last 10 years, to examine current perspectives and recent developments in hyperemesis gravidarum.
متن کاملHyperemesis Gravidarum: A Review of Recent Literature.
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Background & Aims: Due to the importance of a suitable treatment for nausea and vomiting during pregnancy and reducing maternal and fetal complications, and the beneficial effect of Ondansetron in the treatment of nausea and vomiting compared with promethazine, this study was performed. Methods: In this case-control study, 60 pregnant women under 20 weeks of gestation with hyperemesis gravidaru...
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ورودعنوان ژورنال:
- Human reproduction update
دوره 11 5 شماره
صفحات -
تاریخ انتشار 2005